Scientists accidentally made super-vice hamsters in the lab after a glitch in the gene editing test

Scientists accidentally create super-vice hamsters in a lab after a gene editing experiment goes wrong and chases, bites and knocks each other down aggressive rodents

  • Gene editing lab test inadvertently creates hordes of angry hamsters
  • Scientists remove key hormone in hopes it will promote animal cooperation
  • But it made them wild, prompting them to chase, bite and pin among hamsters
  • ‘We [thought] This will reduce aggression. But opposite happened’: exam chief
  • ‘We don’t understand the system as we thought we did’, said the professor

Scientists inadvertently breed a multitude of unusually aggressive hamsters after a gene editing experiment to ‘reduce aggression’ went wrong.

the researchers Georgia State University produced new rodenticides without the hormone vasopressin in an effort to increase ‘social communication’ between rodents.

Yet the chemical change drove Syrian hamsters into the wild, triggering fighting inside the cages.

Ultra-vicious hamsters were depicted pinning, biting and chasing each other.

Scientists share images of genetically modified hamsters in their cages

Scientists share images of genetically modified hamsters in their cages

Hamsters are generally social animals with low levels of aggression and ease of cooperation

Hamsters are generally social animals with low levels of aggression and ease of cooperation

Lead researcher Professor Elliot Albers said: ‘We guessed’ […] We will reduce both aggression and social communication – but the opposite happened.’

The key hormone Avpr1a was thought to regulate friendship and bonding, with its removal expected to increase harmony between animals.

instead of this, laboratory experiment ‘Higher level of aggression towards other same-sex individuals’ was recorded.

Professor Albers said: ‘We were really surprised at the results.’

it was thought that Vasopressin affects hamsters’ social behavior, including aggression and communication.

CRISPR is a gene editing technique in which scientists can ‘snip’ a part of someone’s DNA

To investigate further, the scientists disabled Avpr1a, removing a receptor that interacts with vasopressin in key areas of the brain.

Now being immune to the hormone, it was thought that the rodents would become friendlier.

The results were anything but with an increased frequency of fighting, biting, chasing and pinning among hamsters in their cages.

The study’s startling findings challenge scientists’ understanding of the relationship between biology and behavior.

The professor said: We don’t understand the system as we thought we did.

‘The counterintuitive findings tell us that we should start thinking about the functions of these receptors throughout brain circuits, not just specific brain regions.

‘Growing gene-edited hamsters was not easy. But it is important to understand that the neurocircuitry involved in human social behavior and our model is […] Relevance to human health.’

Professor Albers said the gene editing trials are intended to help find solutions for neuropsychiatric disorders, including autism and depression.

How does crisp DNA editing work?

CRISPR gene editing technology is being used extensively in health research because it can alter the building blocks of the body.

At a basic level, CRISPR works as a DNA cutting-and-pasting operation.

Technically called CRISPR-Cas9, the process involves sending new strands of DNA and enzymes into organisms to edit their genes.

In humans, genes serve as the blueprint for many processes and characteristics in the body – they decide everything from the color of your eyes and hair to whether or not you get cancer.

Components of CRISPR-Cas9 — the DNA sequence and the enzymes needed to implant it — are often sent into the body on the back of a harmless virus so scientists can control where they go.

The Cas9 enzymes can then cut the strands of DNA, effectively turning off genes, or removing sections of DNA that are to be replaced with CRISPR, which are new segments sent to replace the gene and There is an effect they have been pre-programmed to produce.

But the procedure is controversial because it can be used to replace babies in the womb – initially to treat diseases – but there may be a rise in ‘designer babies’ as doctors offer ways to alter fetal DNA .

Source: comprehensive institute

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Author: Admin

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